Structural Hierarchy Governs Fibrin Gel Mechanics

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fibronectin and fibrin gel structure.

Plasma fibronectin is covalently incorporated into alpha-chains of fibrin gels in the presence of Factor XIII activated by thrombin (FXIIIaT) but not by Factor XIII activated by the snake venom enzyme batroxobin (FXIIIaB). FXIIIaB catalyzes introduction of gamma-gamma cross-links in fibrin but cross-linked alpha-chains are not formed. In the presence of FXIIIaT, fibrin gels formed by batroxobin...

متن کامل

Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water.

Blood clots and thrombi consist primarily of a mesh of branched fibers made of the protein fibrin. We propose a molecular basis for the marked extensibility and negative compressibility of fibrin gels based on the structural and mechanical properties of clots at the network, fiber, and molecular levels. The force required to stretch a clot initially rises linearly and is accompanied by a dramat...

متن کامل

Fibrin gel formation in a shear flow.

Blood clots are made up of platelets and fibrin gel, and the relative amount of fibrin is strongly influenced by the shear rate. In order to explore this phenomenon, this paper presents a model of fibrin gel formation over the surface of an injured blood vessel in a shear flow. A condition for gelation including source and sink terms of polymer is derived. A simplified model of coagulation, inv...

متن کامل

Documentary relevance and structural hierarchy

THERE is no writer today more closely identified with research into the idea of relevance as operative within the field of documentation than DONALD J. HILLMAN. It is not certain that he sees any real hope for arrival at any sort of technique capable of producing documentsurrogates relevant to real queries-thus excepting those that satisfy queries derived from ‘source-documents’. Yet, in his pa...

متن کامل

Structural Hierarchy in DNA Hydrogels

Sol-gel transition in aqueous DNA solutions was probed to determine the gelation time tgel and temperature Tgel. It was remarkable to observe that Tgel linearly increased from 36 to 57°C and tgel decreased from 700 to 350 s with increase in DNA concentration. The hydrogels were studied by using small angle neutron scattering (SANS) ([DNA]≤ 3 %(w/v)) to determine the underlying hierarchy of leng...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2010

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2010.01.040